Neuroimaging the Epileptogenic Process

The epileptogenic zone: general principles.

Sir Victor Horsley, a British neurosurgeon, pioneered epilepsy surgery and, in 1886, published the reports of successful cortical resections that resulted in a significant reduction in epileptic seizures in three patients (Horsley, 1886). At that time, V. Horsley assisted by J.H. Jackson (epileptologist) and D. Ferrier (neurophysiologist), identified the region to be resected by the location of...

Using Postmortem hippocampi tissue can interfere with differential gene expression analysis of the epileptogenic process

Neuropathological studies often use autopsy brain tissue as controls to evaluate changes in protein or RNA levels in several diseases. In mesial temporal lobe epilepsy (MTLE), several genes are up or down regulated throughout the epileptogenic and chronic stages of the disease. Given that postmortem changes in several gene transcripts could impact the detection of changes in case-control studie...

Symptomatic epileptogenic lesions.

BACKGROUND AND OBJECTIVES The main aim of this study is to prove the association of seizure types with the MRI findings of the brain (etiological factor). Also, to prove which type of lesion is mostly represented in which age-group, and with which type of seizure. METHODS A total of 100 patients with symptomatic epilepsy, aged from 16 to 80 years, were hospitalized at the Neurology Clinic or ...

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Meditation: Epileptogenic versus antiepileptic influence

To the Editor: Meditation is a widely adopted stress-relieving mental exercise associated with altered cognition and behavior. Recently, there has been debate [1,2] over the influence of meditation, and transcendental meditation (TM) in particular, on epilepsy. This debate was seemingly triggered by a view suggesting a potential epileptogenic influence of meditation [3], implying that long-term...